Diseases characterized by aberrant LL37 expression include, apart from psoriasis, RA, in which LL37 and other AMPs have been found in synovial fluids and circulation (sites of neutrophilic inflammation), SLE, in which LL37 is present in affected organs such as the skin and kidneys, as well as systemic sclerosis (SSc), characterized by high LL37 expression in affected skin [6,7,8,9,10,11,12,13,14,15,16,32,33]. Here, ADSL is linked to systemic sclerosis.