NR1I2 and hepatocellular carcinoma: Interestingly, activation of PXR by a model agonist providing high specificity for the receptor only weakly induces triglyceride accumulation in HepaRG human hepatoma cells, whereas propiconazole and tebuconazole, two much less potent PXR agonists, are much more effective in inducing the accumulation of triglycerides in these cells [16].