Furthermore, the stroma-lymphoma cell-to-cell interaction triggered a feed-forward loop of c-Myc/miR-548m, where activated c-Myc, recruited EZH2 complex (a co-repressor of miR-548m promoter) inducing a sustained reduction of miR-548m and a consequent upregulation of HDAC6. The gene discussed is MYC; the disease is lymphoma.