CHB carriers may pass through disease phases based on their serological profile and HBV DNA and alanine aminotransferase (ALT) levels [18]: (1) HBeAg-positive chronic infection; (2) HBeAg-positive chronic hepatitis; (3) HBeAg-negative chronic infection; (4) HBeAg-negative chronic hepatitis; and (5) the HBsAg-negative phase [18]. The gene discussed is GPT; the disease is chronic hepatitis.