In neuroblastoma cells, Ogata et al. showed that the ER stressors thapsigargin and tunicamycin induce the formation of autophagosomes via the IRE1/JNK pathway, whereas PERK and ATF6 appear not to be involved [37], and that such IRE1/JNK-induced autophagy protects the cells against death induced by ER stress. The gene discussed is ERN1; the disease is neuroblastoma.