Olprinone therapy (Th) significantly reduced levels of IL-6 and RAGE (ARDS/PDE3 vs. ARDS, both p < 0.001), decreased IL-1β (ARDS/PDE3 vs. ARDS, p < 0.01), and increased IL-10 (ARDS/PDE3 vs. ARDS, p < 0.05) (Figure 1). This evidence concerns the gene IL1B and acute respiratory distress syndrome.