Disease-specific misfolded and aggregated proteins have been identified, such as amyloid-β and tau in Alzheimer’s disease, α-synuclein in Parkinson’s disease, huntingtin in Huntington’s disease, and superoxide dismutase 1 and TAR DNA-binding protein 43 (TDP-43) in ALS [142]. Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.