As shown in Section 5.2, the enhanced LUBAC activity is associated with the progression of ABC-DLBCL, and we found that HOIPINs effectively suppressed the cell viability of human ABC-DLBCL cells, but not GCB-DLBCL cells, by inhibiting the linear ubiquitination-mediated NF-κB activation [73]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.