Mitochondrial deacetylation targets of SIRT3, such as peroxisome proliferator-activated receptor-gamma co-activator-1α, mitochondrial electron transport chain Complex I subunit NDUFA9, or Complex II subunit A, mitochondrial ribosomal protein L10 or TCA cycle enzyme isocitrate dehydrogenase 2, have been demonstrated to control a wide range of biological processes including but not limited to gene expression, metabolism, cancer and aging [30,31,32,33,34,35,36,37]. Here, SIRT3 is linked to cancer.