Similarly, through facilitating Blimp-1-mediated IL-10 production in Th17 cells, Sauchinone (SAU), a key bioactive lignin isolated from the roots of Saururus chinensis, ameliorated TNBS-induced colitis and modulated inflammatory responses in mucosal tissues and peripheral blood CD4+ T cells in IBD patients [111]. This evidence concerns the gene CD4 and inflammatory bowel disease.