Moreover, Tbx21 deficiency in IL-17-producing or Rag1-expressing cells had no effect on the generation of IL-17/IFN-γ double-producing cells, but led to a significant absence of Th1-like IFN-γ+ ex-Th17 cells in Helicobacter hepaticus-induced intestinal inflammation, however, the degree of mucosal inflammation was indistinguishable from that observed in control mice [160]. This evidence concerns the gene IFNG and gastroenteritis.