Variants in IL23R, IL12B, JAK2, STAT3, STAT4, PRDM1, and IKZF1 were identified in both UC and CD, implying an important role of T helper (Th)1/Th17 and interleukin (IL)-12/IL-23 pathways toward the pathogenesis of IBD [7,8,9]. The gene discussed is IL23R; the disease is inflammatory bowel disease.