It was supported by the available human data that the percentages of Th17 and Th1/Th17 cells were increased in patients with IBD and a subpopulation of Th17 cells sharing a Th1 signature with high expression of T-bet, CD26, and IL-22 were shown to be involved in mucosal inflammation of CD and UC patients [26,147]. Here, IL22 is linked to inflammatory bowel disease.