On one hand, the frequency of Foxp3+ RORγt+ cells in a Foxp3+ cell population was increased and associated with enhanced IL-23R expression level in colon mucosa during DSS-induced acute and chronic colitis, suggesting the importance of IL-23 signaling related to the instability of Treg cells in the development of IBD [177]. This evidence concerns the gene FOXP3 and inflammatory bowel disease.