For example, the targeted inhibition of Colony-Stimulating Factor 1 Receptor (CSF1R) in LSL-KrasG12D/+;Trp53fl/+;Pdx1-Cre (KPC) genetically engineered mouse models (GEMMs) results in a profound reprogramming of tumor cell-intrinsic pathways from predominantly squamous to classical (pancreatic) (Candido et al., 2018). This evidence concerns the gene CSF1R and neoplasm.