Activation of NF-κB, MAP kinase, and STAT signaling pathways has been reported in CLL (Frank et al., 1997, Herishanu et al., 2011, Ringshausen et al., 2004, Shukla et al., 2018), and CD27 is upregulated in response to B cell receptor engagement (Lafarge et al., 2015). This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.