Deng et al.(28)carried out a prospective multicenter observational study of the efficacy of three individual biomarkers (serum cystatin C - sCysC -, urinary N-acetyl-β-D-glucosaminidase - uNAG -, and the urinary albumin/creatinine ratio - uACR) and their combinations on the early diagnosis of AKI in ICU patients. Here, CST3 is linked to acute kidney injury.