Administration of β-elemene+paclitaxel arrested SKOV3 cell cycle at Sphase and down-regulated CDK1, cyclin-B1, and P27 gene expression andapoptotic-related resistant gene expression of MDR1, LRP, and TS in SKOV3 cells.In vivo experiments showed that treatment withβ-elemene+paclitaxel significantly inhibited ovarian tumor growth and prolongedthe overall survival of SKOV3-bearing mice. Here, CDK1 is linked to ovarian neoplasm.