APOE and atherosclerosis: At the level of the aortic sinus, there was no difference in atherosclerosis area (Fig. 3B), but ESMIRO/ApoE−/−/Nox2−/y mice had evidence of multiple elastin fragmentations in the aortic wall, which were present in ESMIRO/ApoE−/−/Nox2+/y mice in lower numbers (Fig. 3C and Supplemental Fig. S4).