ACHE and Alzheimer disease: Its hallmarks consist in amyloid plaques in the brain anda progressive degeneration of cholinergic innervation of the hippocampusand cerebral cortex.3 Concerning therapeuticoptions, two classes of small molecules are currently available.4 Acetylcholinesterase (AChE) inhibitors(donepezil, rivastigmine, galantamine) act by enhancing acetylcholinelevels, but unsatisfying efficacy and adverse side effects limit theiruse.5 Memantine belongs instead to thesecond class of compounds, and it targets N-methyl-d-aspartate (NMDA) receptors, with modest effects on cognitionin moderate/severe AD.3