Of these, ADAMTSL3 locus had the strongest AD risk association (P = 2.04E‐7), where the minor allele of intronic SNP rs4354897 conferred protection (OR = 0.84, CI = 0.79 to 0.9), only in MAPT H2 non‐carriers, but not in H2 carriers (epistasis P = 1.22E–04). This evidence concerns the gene MAPT and Alzheimer disease.