MITF and melanoma: Indeed, some oncogenes redirect their metabolism to increase mitochondrial oxidation in order to boost the capacity to detoxify ROS caused by different drugs (e.g., MITF in melanomas) (Vazquez et al, 2013), and recent studies have shown increases in OXPHOS metabolism to be associated with resistance to different drugs in various cancer types (Bosc et al, 2017; Farge et al, 2017; Lee et al, 2017).