In particular, mtDNA haplogroup B5b specific tRNAThr G15927A, haplogroup F2 specific ND5 T12338C, haplogroup B4 specific CO1/tRNASer(UCN) G7444A, haplogroup D4 specific tRNAArg T10454C and tRNASer(AGY) C12224T, haplogroup C specific tRNACys G5821A, haplogroup Y2 specific tRNAGlu A14693G variants may increase the risk for hearing impairment among the subjects carrying A1555G mutation [47]. The gene discussed is MT-ND5; the disease is hearing loss disorder.