Multidrug resistance (MDR), which means that the tumor cells may become resistant to structurally and functionally unrelated anticancer agents after chemotherapy, has been reported to be associated with PI3K/Akt signaling pathway in gastric cancer, melanoma, liver cancer, colon cancer, neuroblastoma, breast cancer and leukemia [7]. Here, AKT1 is linked to malignant colon neoplasm.