KL and cardiac hypertrophy: Together with the fact that Klotho‐deficient mice had accelerated vascular calcification and exaggerated pathological cardiac hypertrophy (Xie et al., 2012), and that soluble Klotho ameliorated cardiac hypertrophy in heterozygous Klotho‐deficient mice with CKD (Xie, Yoon, An, Kuro‐o, & Huang, 2015), the above findings suggest that age‐related Klotho deficiency may be a mechanism that promotes pathology in both the kidneys and heart.