AGO1 and hydrops fetalis: Four of the most dominant miRNAs fulfilling the criteria of fold change > 1.5 and P < .05 (commonly used criteria for identifying disease‐associated miRNAs24, 25, 26, 27) between HF and control groups in Ago1 samples are shown in Figure 4: miR‐222‐3p (fold change of 1.7), miR‐497‐5p (fold change of 1.8) and miR‐21‐5p (fold change of 1.6) were up‐regulated in HF patients compared with the healthy control group, whereas expression of let‐7a‐5p (fold change of −1.8) was down‐regulated.