GSEA results showed that glycolysis and oxidative phosphorylation (OXPHOS) pathways were enriched in the gastric tissues in the sf-RON group (Fig. 1c), which was validated by qRT-PCR assay and showed that overexpression of sf-RON and RON significantly upregulated glycolysis and OXPHOS related key enzymes in MKN-45 GC cell lines; interestingly, sf-RON exhibit strong promoting role than RON (Fig. 1d). The gene discussed is MST1R; the disease is gastric cancer.