Early (4 h) after low dose (0.075 Gy), IR BALB/c mice have suppressed immune pathways and macrophage response but increased IL6, COX2, and TGF-β pathway activation in mammary gland compared to the tumor-resistant C57BL/6 mouse (Bouchard et al. 2013; Snijders et al. 2012). The gene discussed is IL6; the disease is neoplasm.