The activating signals are mediated by a wide array of receptors including natural killer group 2-C (NKG2C), natural killer group 2-D (NKG2D), DNAX accessory molecule-1 (DNAM-1), CD161, and natural cytotoxicity receptors NKp30, NKp44, and NKp46 that recognize a variety of stress-induced molecules that may be present on tumor cells. Here, CD226 is linked to neoplasm.