In addition, we also found that mir-146a can reverse the activation of the TLR4/NF-κB pathway caused by CRNDE, and the mir-146a inhibitor can reverse the effect of CRNDE siRNA, suggesting that CRNDE activates the TLR4/NF-κB pathway through regulating mir-146a during the sepsis-induced AKI process. This evidence concerns the gene TLR4 and acute kidney injury.