This implies that the SSB association with obesity is highly dependent on genotype (Figure 2(a), T-allele carriers of PEMT-rs72828480 vs CC; Figure 3(a), C-allele carriers of CHKB-rs75187587 vs AA; and Figure 3(b), TT of ETNK2-rs1106778 vs C-allele carriers) and not solely on SSB intake. This evidence concerns the gene CHKB and obesity due to melanocortin 4 receptor deficiency.