In this study, our data showed that HLA‐G expression in peripheral immune cells such as T cells, B cells and monocytes follows a high–low–high pattern, which may reflect the three stages of infection, replication and clearance of SARS‐CoV‐2; however, receptors ILT2, ILT4 and KIR2DL4 remained relatively stable. The gene discussed is HLA-G; the disease is infection.