In this study, we recorded and analysed the dynamics of peripheral immune cells, the expression of HLA‐G and its receptors ILT2, ILT4 and KIR2DL4 in peripheral immune cells, and the outcomes of a patient infected with SARS‐CoV‐2 (critical COVID‐19) during the 23‐day hospitalisation. Here, LILRB1 is linked to COVID-19.