Interestingly, samples analyzed using MSP (known for its simple design, execution and high sensitivity in the ability to detect small quantities of methylated DNA (Derks et al., 2004[10]; Fackler et al., 2004[12]) revealed a significant association (OR = 5.78, 95 % CI 2.99-11.17, P < 0.001) of HIC1 promoter methylation with cancer risk. The gene discussed is HIC1; the disease is cancer.