SOX2 and neoplasm: Western blot detection showed that hsa_circ_0068307 knockdown downregulated c-Myc and the CSC-related proteins, NANOG, OCT-4, and Sox-2 in tumor tissues (Fig. 5e), which further validated the regulatory role of hsa_circ_0068307/miR-147/c-Myc in in vivo BCa xenograft model.