TNFRSF11B has two known TNF family ligands: TNF related apoptosis-inducing ligand (TRAIL) and receptor activator of nuclear factor (NF)-kB ligand 11.In tumor, TRAIL is produced by monocytes in response to interferon (IFN)-γ or -α and is the principal mediator of acquired tumor killing activity of these cells. The gene discussed is TNFSF10; the disease is neoplasm.