TRAIL binds membrane-bound receptors carrying death domains(DR4 and DR5) [12]and a decoy receptor.TNFRSF11B competes for the binding of TRAIL to death activated receptors, providing a mechanism to prevent apoptosis in the presence of TRAIL.Therefore,TNFRSF11B expression may be an appropriate strategy to avoid TRAIL- induced apoptosis, leading to the development and progression of tumor. Here, TNFSF10 is linked to neoplasm.