Images of tumors that excised subcutaneously from mice showed that tumors in the shNC group were larger than those in the shRAN (#1 and #2) and shHSBP1 (#1 and #2) groups (Figure 6A ), and statistical results of tumor weight and volume also indicated that knockdown of RAN/ HSBP1 inhibited the growth of OC xenograft in vivo (Figure 6B and 6C). The gene discussed is RAN; the disease is neoplasm.