Meanwhile, the results of immunohistochemistry confirmed that shRAN or shHSBP1 caused the down-regulation of Vimentin, N-cadherin, and promoted the expression of E-cadherin (Figure 6F), indicating that the knockdown of RAN and HSBP1 inhibited the invasive ability of ovarian tumor in vivo. This evidence concerns the gene CDH2 and ovarian neoplasm.