Moreover, expression of B7-H3 and tyrosine kinase receptor Tie-2 in clear cell renal cell carcinoma (ccRCC) tumor vasculature were closely related to the progression and prognosis of the disease, while ccRCC angiogenesis was possibly promoted by B7-H3 through the Tie-2 pathway 14. This evidence concerns the gene TEK and nonpapillary renal cell carcinoma.