PADI4 and colorectal carcinoma: In the report on our previous study30, we highlighted PADI4 as an intriguing CRC biomarker possibly reflecting an increased probability of extracellular DNA trap formation47,48 in the mucus overlaying colorectal malignancies.49 The present study has, however, shown that  PADI4 allowed reliably distinguishing CRC patients from healthy volunteers, but failed to do so in the ‘triage’ setting.