The mechanisms by which ionizing radiation can potentiate the antitumor response induced by either an irradiated tumor cell vaccine or local radiotherapy have been explored but remain largely unknown.12,14–17 It has been reported that the cytosolic DNA-STING pathway and canonical NF-κB pathway play important roles in the response to local irradiation.15[,18 However, these studies did not address the potential role of mitochondrial DNA or oxidized mitochondrial DNA in the activation of the STING pathway in response to locally irradiated tumor cells. This evidence concerns the gene STING1 and neoplasm.