The host protein STING has been identified as a central signaling molecule in the innate immune response to cytosolic DNA.45 In addition, enhanced immune sensing, which is induced by oxidized genomic DNA damaged by UV irradiation, is dependent on STING signaling.24 More recently, oxidized mtDNA was reported to participate in the STING-type I IFN axis in lupus.26,27 In our study, we highlight the role of the oxidized mtDNA-STING pathway in eliciting antitumor immunity in response to our irradiated tumor cell vaccine. Here, STING1 is linked to neoplasm.