CALR and neoplasm: Cell-surface exposure of CRT is critical for establishing the immunogenicity of tumor cell death elicited by irradiation, which is involved in the enhanced phagocytosis of irradiated cells by DCs.7,16 Our results revealed that DCs could engulf more irradiated EG7 cells than untreated EG7 cells and that oxidized mtDNA was delivered to the cytoplasm of DCs after irradiated tumor cell vaccination and subsequently elicited antitumor immunity.