Oxidized mtDNA, as a DAMP or adjuvant, activates the STING-TBK1-IRF3-IFN-β pathway in DCs, which is followed by cross-presentation of irradiated tumor cell-derived antigens to CD8+ T cells and potentiation of the antitumor effect of the irradiated immunogenic tumor cell vaccine. The gene discussed is TBK1; the disease is neoplasm.