CD8A and hypertensive disorder: One study suggests that mineralocorticoid receptor on CD8+ T cells directly sense blood pressure and promote inflammatory milieu through secreting IFN-γ.20,21 Furthermore, hypertension can trigger oxidative modification of proteins in DC cells by highly reactive γ-ketoaldehydes (isoketals), which activate DC to produce IL-6, IL-1β, and IL-23.