GNB1 and diffuse large B-cell lymphoma: Loss of expression of major histocompatibility complex class II (MHC II) genes and associated genes such as the HLA-DR antigen-associated invariant chain (HG2A or CD74) has been related to the non-GCB subtype and an inferior overall survival in R-CHOP-treated DLBCL patients due to impaired antigen presentation and immune surveillance48.