RUNX1T1 and acute myeloid leukemia: Similar findings were present in Hi-C data from AML cell lines with the same mutations, including OCI-AML3 and IMS-M2 cells with the NPM1c mutation and the Kasumi-1 cell line with the RUNX1-RUNX1T1 gene fusion, which showed that NPM1c-containing cells had more loops and a shift in the loop anchors toward the posterior HOXA cluster (Fig. S6A–C).