PKD1 and autosomal dominant polycystic kidney disease: With 10%, the amount of PKD1/2-negative patients resembles the rate in other, ethnically divergent cohorts from India (15%), Italy (20%), France (10%), China (14%), and Japan (17%).3,23,27–29 Taken together, these data indicate inaccuracy of clinical ADPKD diagnoses in at least 10% of cases and about twice as much if VUS carriers are strictly counted as nondiagnostic (additional 9% in our cohort).