GANAB and kidney disorder: In contrast to his father, however, he also showed an additional VUS in GANAB/PKD3 (c.602A>G, p.Asp201Gly, no entry in gnomAD/HGMD) potentially explaining the accelerated course of renal disease (Fig. 4) (ESRD-onset at 30 vs. ESRD-onset at 56 yrs).