LRP5 and Renal cyst: The affected amino acid residue lies within the second WD40-repeat of the Wnt coreceptor LRP5 (low-density lipoprotein receptor-related protein 5), a domain that was recently associated with cystic kidney and liver disease22 (MIM 617875) by identification of a neighboring tryptophan change (p.Trp560Cys), potentially indicating incomplete penetrance in this family (Table S4, Fig. S2).