TSC1 and Pancreatic cysts: Lastly, in ID35.1, a 64-year-old male with positive family history, bilateral oligocystic kidney disease, a pancreatic cyst formation, and moderately impaired kidney function (CKD stage 3b with an eGFR at 41 ml/min), we detected a novel heterozygous TSC2 missense variant (c.2140C>T, p.Pro714Ser) affecting the well-conserved tuberin domain, a region in which missense variants have commonly been associated with tuberous sclerosis complex (TSC, MIM 613254).