MBNL1 and acute myeloid leukemia: Given that the number of in vivo and in vitro overlapping splicing events was relatively low, we more broadly examined concordance of MBNL1 knockdown AS events among major genetically/cytogenetically defined AML subtypes, including nearly 500 splicing factor knockdowns in K562 or HepG2 cells (ENCODE; Encyclopedia of DNA Elements) and normal hematopoetic cell types.