DOT1L and leukemia: Our data shows the effect of MBNL1 at the mRNA and protein level, and suggests that MBNL1 plays a key role in the pathogenesis of MLL-rearranged leukemia by stabilizing the transcripts of multiple leukemogenic genes including DOT1L and SETD1A; this in turn supports transcriptional activation of downstream targets of the MLL-fusion protein, including activation of MBNL1, creating a positive feedback loop (Fig. 8).