Recent liver fibrosis research focused mainly on infiltrating monocyte/macrophages recruited to the liver from bone marrow, with some of specific subsets identified as functionally promoting fibrosis progression (CD11b(+)F4/80(+)Gr-1(+))24 or reversal (CD11b(hi)F4/80(int)Ly-6C(lo))25. This evidence concerns the gene ITGAM and Hepatic fibrosis.