Our protein panel included neurosecretory protein VGF (VGF), LINGO1, CNTNAP4, NRXN3, NXPH1, PCSK1N, SERPINI1, CARTPT, GRIA4, NPTXR, and CBLN4, which all showed significant downregulation in the CSF of MDD in comparison to the controls in the discovery approach (Student’s t test, permutation-based FDR < 0.05). This evidence concerns the gene CBLN4 and major depressive disorder.