The adaptation of cellular metabolism by the tumor is particularly important for maximizing energy acquisition.7 ENO2, also referred to as NSE, is an important enzyme in glycolysis and a well-established tumor biomarker for small-cell lung cancer, prostate cancer, and so on.15 Studies have found that ENO2 is essential for cancer cell survival, proliferation and progression in glioblastoma multiforme and HCC.16,29 However, the function of ENO2 in pancreatic cancer has not been fully clarified. Here, ENO2 is linked to hepatocellular carcinoma.