IL6 and head and neck squamous cell carcinoma: With regard to Be2 signature genes, the B-cell stimulatory cytokine IL237 was the most elevated in TIL-B-high HNSCC/CESC/LUAD, while IL6, a pro-inflammatory signal for cancer progression and initiation of germinal center formation38,39, was elevated in TIL-B-high KIRP/LGG tumors (Fig. 2f, g).