For HNSCC prognosis, Cox-regression revealed that quantitative levels of TIL-B (P = 0.0015, hazard ratio [HR] = 0.082) and MS4A1 (P = 0.00447, HR = 0.936), but not quantitative CD20 protein levels (P = n.s). This evidence concerns the gene MS4A1 and head and neck squamous cell carcinoma.