Taking advantage of the recent availability of quantitative proteomics, transcriptomic, and survival data of TCGA-HNSCC cohort, we unbiasedly cross-compared the prognostic values of intratumoral CD20 protein, CD20 mRNA (encoded by the gene MS4A1), and TIL-B levels by univariate Cox-regression analyses. The gene discussed is MS4A1; the disease is head and neck squamous cell carcinoma.