Importantly, for the immunosuppressive BK signature gene, PD-L2, TIL-B-high KIRP/LGG showed the greatest upregulations of 2.2–2.4 log2 fold increases (=3.1-fold in linear scale) as compared with only 1.1–1.3 log2 fold increases (=1.4–1.5-fold in linear scale) in TIL-B-high LUAD/HNSCC/CESC (vs. their respective low-TIL-B tumors, Fig. 2f, g). The gene discussed is KNG1; the disease is head and neck squamous cell carcinoma.