In HNSCC, the favorable prognostication of high MS4A1 and TIL-B levels identified in our study are consistent with a recent finding on the presence of high percentage of activated B-cell, antigen-presenting B-cells in HNSCC patient tumors, supportive of potential antitumor activity of TIL-B in this cancer type30. The gene discussed is MS4A1; the disease is head and neck squamous cell carcinoma.