Here, based on the recent availability of highly quantitative multiomics data from the Cancer Genome Atlas (TCGA) (transcriptomic data from RNA-Seq) and the proteomic data from the Cancer Proteome Atlas (TCPA, by reverse phase protein array, RPPA) which allow quantifiable and potential functional investigations of various TILs in pan-cancers, we unbiasedly compare the prognostic powers of quantitative CD20 protein, mRNA, and TIL-B levels in 29 TCGA cancer types including HNSCC (a total of 9963 primary human tumors). Here, MS4A1 is linked to head and neck squamous cell carcinoma.