Di Forti et al.37, replicated the Van Winkel et al.39 case-control data, showing that CC genotype carriers of AKT1 with a history of cannabis use showed a two-fold increase in the ORs for a psychotic disorder, in comparison to TT carriers and an interaction with the genotype and frequency of use was found on case/control status. Here, AKT1 is linked to psychotic disorder.