NEFL and Alzheimer disease: Though few CU participants had elevated tau PET values, half had ITC SUVR values 20%–30% above the reference region, in line with the known association between cognition and tau PET signal within this region.14 The distribution of (N) biomarkers across the best models (CU: 3/5 [N]2, 2/5 [N]3; CI: 3/5 [N]1, 2/5 [N]2) may reflect variability in the patterns of neurodegeneration biomarkers across the AD continuum,29 with CSF NfL being most dynamic during the preclinical disease phase,7,30 similar to CSF Aβ42 and p-tau.