MAPT and Alzheimer disease: Given that the deposition of Aβ and phosphorylated tau mediated the neurofibrillary tangles are two main core pathological features of AD, we asked whether paroxetine treatment affected the accumulation of Aβ in AD mice, and evaluated Aβ immunoreactivity in brain sections from saline-treated and paroxetine-treated AD mice using antibody 6E10.