APP and Alzheimer disease: As the results shown, the saline-treated APP/PS1 mice showed obvious memory deficit with a significantly decreased freezing time compared to saline-treated WT mice in both context A and context B test, while paroxetine treatment resulted in a significant restoration in freezing time comparable to the saline-treated AD mice (Fig. 2a, b). These results suggested that paroxetine early treatment is benefit for memory deficit rescue of AD mice.