While recombinant cystatin C therapy has not yet been investigated, treatment with recombinant cystatin from Schistosoma japonicum improved outcomes in 2,4,6-Trinitrobenzenesulfonic acid-induced murine model of colitis [206], highlighting the potential for similar therapies involving recombinant cystatin C. Alternatively, the targeting of other CTSS regulators including PP2A, IFNγ or IL-6 has shown positive outcomes in initial preclinical studies [207–210]. Here, CST3 is linked to colitis.