Collectively, these findings may help reveal the role of the SPI1-METTL14-MYB/MYC signaling axis in hematopoiesis and leukemia [148].WTAP was found to be upregulated in AML cells and to play an important role in the abnormal proliferation of leukemia cells and the inhibition of their differentiation, suggesting WTAP as a potential new therapeutic target for AML [149]. This evidence concerns the gene SPI1 and acute myeloid leukemia.