m6A modification of WTAP was found to result in posttranscriptional inhibition of ETS1, another mechanism by which the p21/p27-dependent pathway could regulate the cell cycle in HCC cells [110].YTHDF2 had an inhibitory effect on HCC, which inhibited tumor cells and vessels by processing interleukin 11 (IL11) and serpin family E member 2 (SERPINE2) mRNA. This evidence concerns the gene SERPINE2 and hepatocellular carcinoma.