Zhou et al. analyzed 162 cases of HCC in the TCGA database and the GSE14520 and GSE63898 datasets and found that the combination of METTL3 and YTHDF1 levels could be used as a biological index to reflect the degree of malignancy and evaluate the prognosis of HCC [102]. This evidence concerns the gene METTL3 and hepatocellular carcinoma.