Thus, YTHDF1 plays an important role in the progression of CRC [126].lncRNA-GAS5 binds directly to the WW domain of YAP in CRC and promotes its phosphorylation and ubiquitin-mediated degradation, thereby weakening YAP-mediated YTHDF3 transcription. This evidence concerns the gene YTHDF1 and colorectal carcinoma.