Additionally, FTO was found to promote melanoma growth, while knockout of FTO increased m6A methylation of important genes in malignant melanoma cells, including PD-1, C-X-C motif chemokine receptor 4 (CXCR4), and SRY-Box transcription factor 10 (SOX10), and increased the RNA decay through YTHDF2, which further increased the sensitivity of mouse melanoma cells to interferon gamma (IFNγ) and anti-PD-1 treatment. The gene discussed is CXCR4; the disease is melanoma.