FTO was found to promote leukemia oncogene-mediated cell transformation and leukemia, inhibit the differentiation of AML cells induced by all-trans retinoic acid (ATRA), and regulate the expression of its target genes, such as ankyrin repeat and SOCS box containing 2 (ASB2) and retinoic acid receptor alpha (RARA), by decreasing the m6A level in mRNA transcripts [150]. The gene discussed is FTO; the disease is acute myeloid leukemia.