MAPK8 and liver dysplastic nodule: A large number of evidence indicates that the activation of the signal transduction pathway of the three important members of the MAPK family, namely p38 MAPK, JNK and ERK, is closely associated with the development of DN, particularly the p38 Mitogen-activated protein kinase (MAPK) signal transduction pathway, which is activated in DN and may promote the occurrence and development of DN by affecting the formation of ECM, apoptosis and cytokines [17].