IL17A and ankylosing spondylitis: Amongst the six trials (four trials of secukinumab and two of ixekizumab) focusing on the efficacy of IL-17 inhibitors in ankylosing spondylitis, 1153 patients received IL-17 inhibitor therapy (777 of secukinumab and 376 of ixekizumab) and 580 patients received a placebo (389 patients were used as comparators for secukinumab and 191 for ixekizumab).